Hydrolysis of diadenosine 5',5''-P',P''-triphosphate (Ap3A) by porcine aortic endothelial cells.
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منابع مشابه
Hydrolysis of diadenosine 5',5''-P',P''-triphosphate (Ap3A) by porcine aortic endothelial cells.
Diadenosine triphosphate is present in platelet-dense granules and released quantitatively on platelet aggregation. We have found that intact porcine aortic endothelial cells can efficiently hydrolyze extracellular diadenosine triphosphate. The products of diadenosine triphosphate hydrolysis are adenosine monophosphate and adenosine diphosphate. Adenosine diphosphate is a potent stimulus of pla...
متن کاملCultured Porcine Aortic Endothelial Cells
Hemodynamic shear stress alters the architecture and functions of vascular endothelial cells. We have previously shown that the synthesis of endothelin-1 (ET-1 ) in endothelial cells is increased by exposure to shear stress. Here we examined whether shear stress-induced alterations in cytoskeletal structures are responsible for increases in ET-1 synthesis in cultured porcine aortic endothelial ...
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pressure in humans with hypertensive disease. J Clin Invest 43: 659669.1974 21. Rnguska J, Simon NM, DelGreco F: Pressor response to angiotensin II in hypertension. Am J Cardiol 21: 705-713, 1968 22. Conn JW, Cohen EL, Rovner DR: Suppression of plasma renin activity in primary aldosteronism. JAMA 190: 213-221, 1964 23. Sealey JE, Gerten-Banes J, Laragh JH: The renin system: Variations in man me...
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Cultured porcine aortic endothelial cells were conditioned through two passages to mimic euglycemic and hyperglycemic conditions (5.2 mM, normal glucose; 15.6 mM, elevated glucose). After incubation with 1 microM [14C]arachidonic acid for 24 h, the cells were stimulated with 1 microM A23187 for times up to 30 min. Uptake of [14C]arachidonic acid and its distribution among cell lipids were unaff...
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The hydrolysis of ATP by acto-HMM has been studied during the transient state using a rapid-mixing apparatus. The rate of substrate binding was slightly slower and the rate of hydrolysis of the first molecule of ATP was essentially the same as for heavy meromyosin (HMM) alone. The rate of acto-HMM dissociation after binding substrate was too fast to measure in a stopped-flow apparatus, conseque...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1986
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.59.3.362